I. Abstract (max 2000 chars). Organize the abstract into separate sections:
- Broad objectives
- Background and Rationale
- Research design and methods for achieving the stated objectives
- Relevance and Anticipated output
II. Background and Rationale (max 8000 chars). Present background information and a rationale for the proposed study plan using the scientific literature and previously published or preliminary data (if available).
III. Preliminary results (max 5000 chars). In order to support your hypothesis, if possible please provide any preliminary data produced in your lab that is pertinent to the proposed study. However, preliminary data is not mandatory for this type of funding initiative.
IV. Research Plan (max 12000 chars). List the Specific Aims of the project. Provide a description of each one and of the experimental plan to achieve it. Explain the aim for collaborations, if any. Provide a timeline for the different Specific Aims (Gantt chart or similar).
V. Collaborations (max 5000 chars). Please note that budget cannot be allocated for collaborators. If collaborations are envisaged, indicate who the collaborators are (specifying name and institution and providing a brief bio sketch) and describe the approaches each collaborator will bring to the overall study. Please note that all listed collaborations must be supported by collaboration letters written in English, which must be attached to the proposal.
VI. Cited Literature (max 20000 chars). List all references. The list must include the names of all authors, year of publication, title, book or journal, volume number and page numbers.
VII. Host Institution. Provide information about the facilities and resources available for you at the Host Institution, including lab and office space, major equipment and core facilities and services available. The Host Institution (HI) has to provide a letter of acceptance of the project being conducted within the Institution itself (Host Institution Agreement). The letter must be signed by the Director or other Responsible Official of the HI. The letter has to be sent as pdf together with proposal. Failure to submit the Host Institution Agreement may result in exclusion from review (please find the form for HI Agreement here).
VIII. Budget. The maximum budget allowed is € 40,000 (forty thousand euros). Please arrange the budget into a table followed by a paragraph for budget description/justification. The table should list the following items and the related expenses in Euro (use whole numbers only):
– Materials, Supplies, Services: List by category: Services include items such as Animal Housing (justify the total no. of animals needed and the cost per diem), Sequencing, Peptide Synthesis, etc. Major cost items should be listed and properly justified.
– The salary of only one project’s staff member (postgraduate, postdoc, technician, etc.) The salary should be determined by the time spent dedicated to the project.
– Other expenses: i.e. publication costs, samples, animal shipments and others.
Please note that the following costs are not covered:
– Equipment of any type
– Salary for Principal Investigator
IX. Other financial support. List all financial support available or grant applications pending in your lab that are pertinent to research on NBIA, including: title of grant, coordinator, funding body, budget, funding period, research supported by the grant (two lines).
X. Personnel. List the people involved in the project indicating: name, surname, date of birth, degree, role on the project, type of contract at the Host Institution, end date of contract, if the salary has been requested, annual effort on the project (% of time).
XI. Lay summary (max 5000 chars). This section is crucial for the lay evaluation that will be performed by the Lay Review Committee (LRC). The LRC is comprised of nine representatives from the NBIA family community who are nominated by the funding organizations. LRC members will evaluate and select only projects that are recommended for funding by the SAB. The lay reviewer’s role is not to comment on the quality of research or on the science behind it, but to ensure that the research aims are aligned with the scopes of the funding organizations and of paramount importance to NBIA families. To facilitate the lay review, provide a description of the project avoiding the use of jargon, complex terms and phrases and use plain English. Focus on the significance of the research and how it will be instrumental for the design of novel disease-modifying therapies.